FOXP2 as a molecular window into speech and language

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چکیده

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FOXP2 as a molecular window into speech and language.

Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits. Recent genomic investigations indicate that its downstream neural targets make broader impacts on common language impairments, bridging clinically distinct disorders. Moreover, the striking conservation of both FoxP2 sequence and neural expressio...

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ژورنال

عنوان ژورنال: Trends in Genetics

سال: 2009

ISSN: 0168-9525

DOI: 10.1016/j.tig.2009.03.002